View all news

Oklo, NVIDIA, and Los Alamos National Laboratory Collaborate to Advance Nuclear Fuel Validation at Los Alamos in Support of Nuclear-Powered AI Factories

04/23/2026

The agreement brings together advanced nuclear reactors, AI models, and national laboratory expertise to support critical nuclear infrastructure for the federal government’s Genesis Mission.

Oklo Inc. (NYSE: OKLO) (“Oklo”), an advanced nuclear technology company, today announced an agreement with NVIDIA, a leader in AI and accelerated computing, and Los Alamos National Laboratory (LANL), to advance critical nuclear infrastructure, AI-enabled research, and nuclear fuel R&D at Los Alamos.

Oklo Aurora powerhouse (Image: Oklo)

Oklo Aurora powerhouse (Image: Oklo)

The collaboration is intended to combine advanced nuclear power, AI, digital twins, modeling, and simulation to support critical infrastructure development and accelerate the deployment of nuclear energy. By aligning Oklo’s advanced sodium-fast-reactor platform, NVIDIA AI infrastructure, and LANL’s world-leading expertise in materials science and nuclear fuels, the parties aim to lay the groundwork for a new class of mission-critical, high-assurance energy.

“This agreement brings together reactor deployment, high-performance compute, and world-class fuel and materials science expertise” said Oklo co-founder and CEO Jacob DeWitte. “We believe this will advance our plutonium-bearing fuel work on Oklo’s Pluto reactor, which was selected under DOE’s Reactor Pilot Program, and help bring resilient power in support of the Genesis Mission.”

Initial focus areas include:

  • Physics- and chemistry-based AI models, including trained inference models to support fuel validation and R&D for plutonium-bearing fuels
  • Materials science and fabrication R&D for plutonium-bearing fuels
  • Power generation, grid reliability, redundancy and stabilization studies in support of nuclear-powered AI factories at LANL

Projects under the agreement include integrated full-stack solutions to support nuclear powered AI factories; AI development, including physics and chemistry trained AI models to support nuclear fuel R&D; grid stabilization, reliability, and redundancy studies; materials science efforts focused on plutonium-bearing fuel; and proof of concept work related to the development of a nuclear powered AI factory.

About Oklo Inc.: Oklo Inc. is developing fast fission power plants to deliver clean, reliable, affordable energy at global scale; establishing a domestic supply chain for critical isotopes; and advancing nuclear fuel recycling to convert used nuclear fuel into clean energy. Oklo was the first to receive a site use permit from the U.S. Department of Energy for a commercial advanced fission plant, was awarded fuel from Idaho National Laboratory, and submitted the first custom combined license application for an advanced reactor to the U.S. Nuclear Regulatory Commission. Oklo is also developing advanced fuel recycling technologies in collaboration with the U.S. Department of Energy and U.S. National Laboratories.

Forward-Looking Statements

This press release includes statements that express Oklo’s opinions, expectations, objectives, beliefs, plans, intentions, strategies, assumptions, forecasts or projections regarding future events or future results and therefore are, or may be deemed to be, “forward-looking statements.” The words “may,” “will,” “could,” “should,” “expects,” “anticipates,” “intends,” “plans,” “believes,” “seeks,” “estimates,” “continue,” “might,” “possible,” “potential,” “predict,” “project,” “goal,” “would,” “commit,” or, in each case, their negative or other variations or comparable terminology, and similar expressions may identify forward-looking statements, but the absence of these words does not mean that a statement is not forward-looking. These forward-looking statements include all matters that are not historical facts. They appear in a number of places throughout this press release and include statements regarding our intentions, beliefs or current expectations concerning, among other things, results of operations, financial condition, liquidity, prospects, growth, strategies and the markets in which Oklo operates. Such forward-looking statements are based on information available as of the date of this press release, and current expectations, forecasts and assumptions, and involve a number of judgments, risks and uncertainties.

As a result of a number of known and unknown risks and uncertainties, the actual results or performance of Oklo may be materially different from those expressed or implied by these forward-looking statements. The following important risk factors could affect Oklo’s future results and cause those results or other outcomes to differ materially from those expressed or implied in the forward-looking statements: risks related to the development and deployment of Oklo’s powerhouses, fuel fabrication and fuel recycling facilities, and radioisotope production activities; the risk that Oklo is pursuing an emerging market with no commercial project operating and regulatory uncertainties; risks related to acquisitions, divestitures, or joint ventures we may engage in; the need for financing to construct plants, which remain subject to market, financial, political, and legal conditions; risks related to an inability to raise additional capital to support our business and sustain our growth on favorable terms; the effects of competition; risks related to accessing high-assay low-enriched uranium, plutonium, and other fuels (including recycled fuels) at acceptable costs and under acceptable timelines; risks related to our supply chain; risks related to power purchase agreements; risks related to human capital; risks related to our intellectual property; risks related to cybersecurity and data privacy; changes in applicable laws or regulations, including tariffs; the outcome of any government and regulatory proceedings and investigations and inquiries; and the other factors set forth in our documents we have filed with the U.S. Securities and Exchange Commission (the “SEC”).

The foregoing list of factors is not exhaustive. You should carefully consider the foregoing factors and the other risks and uncertainties of the other documents filed by Oklo from time to time with the SEC. The forward-looking statements contained in this press release are based on current expectations and beliefs concerning future developments and their potential effects on Oklo. There can be no assurance that future developments affecting Oklo will be those that Oklo has anticipated. Oklo undertakes no obligation to update or revise any forward-looking statements to reflect events or circumstances after the date of this presentation, except as may be required by law.

Media and Communications for Oklo:
Bonita Chester, Head of Communications and Media at media@oklo.com

Investor Contact:
Sam Doane, Senior Director of Investor Relations at investors@oklo.com

Source: Oklo Inc.

Multimedia Files:

View all news